WeihuaWeihua

Brand Introduction

Guangzhou Weihua Biotechnology Co., Ltd. is a modern R&D and manufacturing enterprise specializing in bioreagents, deeply engaged in the biopharmaceutical field and driven by technological innovation at its core. The company has always adhered to its core mission of "innovating and creating for China, empowering and supporting scientific research," focusing on the R&D, production, and customized services of high-quality research-grade reagents and biomaterials, providing globally the biopharmaceutical research and bioengineering fields with high cost-effectiveness, high-stability core raw materials and comprehensive solutions.

Core Strengths

At its inception, the company assembled a highly professional and dynamic R&D team and established deep collaborations with Ph.D. holders and professors from multiple universities. The company plans to build over 3,600 square meters of office space and 2,500 square meters of standardized laboratories, equipped with internationally first-class instrument and equipment platforms, including:

Peptide Synthesis and Purification: CS Bio CS336X peptide synthesizer, freeze dryer

Analytical Testing: Agilent LC-MS liquid chromatography-mass spectrometry system, GC-MS gas chromatography-mass spectrometry system, Bruker 600MHz nuclear magnetic resonance spectrometer (NMR), atomic fluorescence spectrometer, nano Fourier transform infrared spectrometer (Nano-FTIR), UV-Vis spectrophotometer

Structural Characterization: Transmission electron microscope (TEM), Krios G3i cryo-electron microscope (Cryo-TEM)

Relying on a complete "R&D—Production—Testing" full-chain capability, the company can provide customers with one-stop services from molecular design and customized synthesis to quality analysis.

Quality Management

The company strictly follows relevant management regulations, has formulated advanced management systems and scientific production process standards, continuously strengthens employee skills training and internal quality audits; meanwhile, it selects high-quality global reagent and raw material custom manufacturers, deeply explores high cost-effectiveness raw material supply chains, and comprehensively ensures stable and reliable product quality.

Customers and Services

The company always takes customers' real needs as its starting point and is guided by sincere and comprehensive customer service. Its customer base covers biopharmaceutical research institutions such as universities, hospitals, and research institutes, as well as multiple biopharmaceutical enterprises and research institutions distributed across many countries and regions worldwide.

Product System

I. Custom Small Molecule Synthesis

Custom synthesis of various pharmaceutical intermediates, functional small molecules, heterocyclic compounds, lipid small molecules, targeting ligands, and linker small molecules; purity and molecular weight can be adjusted on demand, with gram-scale to kilogram-scale preparation available.

II. Synthetic Phospholipids - PEG Derivatives

DSPE-PEG multifunctional modification series, capable of freely conjugating various functional ligands: DSPE-PEG - peptides, DSPE-PEG - small molecule drugs, DSPE-PEG - fluorescent dyes, DSPE-PEG - proteins, DSPE-PEG - carbohydrates, DSPE-PEG reactive functional groups (amino, carboxyl, maleimide, azide, alkynyl, sulfhydryl, etc.)

III. Modified Phospholipids

Base phospholipids: DSPE, DOPE, DMG; derivatizable modifications: phospholipid - drug conjugates, phospholipid - fluorescence, phospholipid - protein, phospholipid - carbohydrate, phospholipid - reactive groups, phospholipid - polymers, suitable for liposome and LNP preparation.

IV. Cationic Lipids and Liposome Excipients

Core cationic lipid raw materials: classic transfection/delivery lipids such as DOTAP, DOTAM, MC3; a full set of liposome excipients including neutral lipids, helper lipids, solubilizing excipients, and membrane stabilizers.

V. Peptide & Protein Modification Reagents and Customization

· Functional peptides: targeting peptides, fluorescently labeled peptides, cell-penetrating peptides, neuroactive peptides, tag peptides

· Protein derivative modification: peptide - drug conjugation, peptide - fluorescence, peptide - polysaccharide, peptide - PEG custom modification

VI. Polysaccharide/Monosaccharide Derivative Synthesis

Polysaccharide backbone modification of hyaluronic acid (HA), dextran (Dex), glucose, heparin, etc.; graftable with fluorescence, drugs, PEG, peptides, biotin, and responsive bonds, for targeted carriers, hydrogels, and bioimaging.

VII. Biotinylation Labeling Reagents

Biotin conjugation with a full range of substrates: labeled small molecule drugs, peptides, proteins, polysaccharides, phospholipids, suitable for ELISA, fluorescent tracing, and affinity purification experiments.

VIII. Fluorescent Dyes and Fluorescent Labels

Core dyes: cyanine CY series, indocyanine green (ICG), rhodamine B (RB), fluorescein isothiocyanate (FITC), coumarin, etc.;One-stop fluorescent conjugation: fluorescent-protein, fluorescent-small molecule drug, fluorescent-polysaccharide, fluorescent-polypeptide, fluorescent-phospholipid PEG, dedicated for in vivo imaging and cell tracking.

IX. Block Polymers

PLGA, PCL, PLA degradable polyester materials; PLGA-based injectable hydrogels; supporting customization of different copolymer ratios and molecular weights, used for microspheres, nanoparticles, and sustained-release scaffolds.

X. PEG Derivative Modification Series

Methoxy PEG, heterobifunctional PEG, multi-arm PEG, branched PEG, with full coverage of reactive end-group PEGs such as amino/carboxyl/maleimide/azide/alkynyl/biotin/fluorescent, suitable for conjugation with various biomolecules.

XI. Stimuli-Responsive Drug Carrier Linkages

1. ROS reactive oxygen species-responsive linkages

-TK - thioketal, -PPS - poly(phenylene sulfide), -Se-Se - diselenide bond

2. pH acidic-responsive linkages

-Hyd - hydrazone bond, PEOz poly(2-ethyl-2-oxazoline), PAE poly(β-amino ester)

3. GSH glutathione reduction-responsive linkages

-SS - disulfide bond. Responsive linkages can be incorporated into phospholipids, PEG, polypeptides, polymers, and polysaccharide carriers to construct tumor microenvironment-targeted drug delivery systems.

XII. Custom Synthesis of Liposomes and LNP Nanoparticles

Relying on in-house raw materials including phospholipids, cationic lipids, and responsive linkages, we undertake custom preparation of various drug-loaded liposomes, nucleic acid LNPs, and fluorescent tracer nanoparticles at pilot and scale-up scales.

XIII. Stable Isotope-Labeled Products

Carbon-13, deuterated D, nitrogen-15 and other isotope-labeled small molecules, phospholipids, polypeptides, polysaccharides, and drug intermediates, used for metabolomics, mass spectrometry quantification, and tracer experiments.