HiActi® Recombinant Human TPO/Thrombopoietin Protein, His Tag 重组人TPO蛋白

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巨核细胞生成与血小板生成造血干细胞生物学

Product no.92252ES Sizes2 options SourceYeasen · Official

Cat. No. 92252ES60

现货 $6,875.00

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92252ES60 100 μg $6,875.00 现货 Enquire

92252ES80 1 mg $36,425.00 现货 Enquire

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Overview

Specifications

Brand翌圣生物 Yeasen

Cat.No92252ES

Specification高纯度、高活性、低内毒素、高批间一致性

Origin翌圣生物科技(上海)股份有限公司

应用方法 巨核细胞生成与血小板生成关键调节因子 造血干细胞生物学关键调控因子

适用物种种属人

检测方法 LAL法 SDS-PAGE 细胞增殖实验

生物特性参数 蛋白类型重组蛋白 种属来源人 生物活性描述TPO是巨核细胞生成和血小板生成的关键调节因子。TPO及其受体（c-Mpl）是巨核细胞和血小板生成的主要调控因子，在造血干细胞（HSC）生物学中发挥着关键且不可或缺的作用。TPO通过Jak-STAT、Ras-Raf-MAPK和PI3K信号通路发挥作用，促进巨核细胞的存活、增殖和多倍体化。Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 for this effect is typically 10-60 ng/mL.

技术参数纯度> 90% as determined by SDS-PAGE. 内毒素水平< 1.0 EU per μg by the LAL method. 分子量Approximately 37.6 kDa. As a result of glycosylation TPO migrates as an approximately 78.2 kDa band in SDS-PAGE under reducing conditions. 制剂形式Lyophilized from a 0.2 μm filtered concentrated solution in PBS pH 7.4. 活性Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 for this effect is typically 10-60 ng/mL. 储存条件-25 ~ -15℃保存，收到货之后有效期1年。 表达系统HEK293 标签N-His 外观Lyophilized Powder 复溶方法We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water(400 μL)to a concentration of0.25mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions. 表达序列Ser 22-Gly 353 AccessionNP_000451.1