Literature国际期刊 |转染试剂与反转定量产品登Science
2022年10月14日,中国科学院微生物研究所刘翠华团队与北京师范大学邱小波团队合作,在Science期刊发表研究论文(IF=63.714)。该研究揭示了结核分枝杆菌利用脂磷酸酶PtpB挟持宿主泛素进而拮抗GSDMD介导的细胞焦亡的病原免疫逃逸新机制,提供了基于病原-宿主互作界面的结核病治疗新思路和潜在新靶标。



国际期刊 | 翌圣qPCR荣登高分杂志!circVAMP3或成肝细胞癌治疗靶点
转染试剂系列(滑动查看)
[1] Liu R, Yang J, Yao J, et al. Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins. Nat Biotechnol. 2022;40(5):779-786. doi:10.1038/s41587-021-01112-1(IF=68.164)
[2] Luo J, Yang Q, Zhang X, et al. TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile. Cell. 2022;185(6):980-994.e15. doi:10.1016/j.cell.2022.02.010 (IF=66.85)
[3] Zhou J, Chen P, Wang H, et al. Cas12a variants designed for lower genome-wide off-target effect through stringent PAM recognition. Mol Ther. 2022;30(1):244-255. doi:10.1016/j.ymthe. 2021.10.010 (IF=12.910)
[4] Chen S, Cao X, Zhang J, Wu W, Zhang B, Zhao F. circVAMP3 Drives CAPRIN1 Phase Separation and Inhibits Hepatocellular Carcinoma by Suppressing c-Myc Translation. Adv Sci (Weinh). 2022;9(8):e2103817. doi:10.1002/advs.202103817 (IF=17.694)
[5] Zhang Y, Yu X, Sun R, et al. Splicing factor arginine/serine-rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome-based cellular communication. Clin Transl Med. 2022;12(2):e684. doi:10.1002/ctm2.684 (IF=11.492)
[6] Qin J, Cai Y, Xu Z, et al. Molecular mechanism of agonism and inverse agonism in ghrelin receptor. Nat Commun. 2022;13(1):300. Published 2022 Jan 13. doi:10.1038/s41467-022-27975-9 (IF=17.681)
[7] Tang X, Deng Z, Ding P, et al. A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing. J Exp Clin Cancer Res. 2022;41(1):85. Published 2022 Mar 8. doi:10.1186/s13046-022-02276-7(IF=12.658)
[8] Yang X, Wang X, Xu Z, et al. Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1 [published online ahead of print, 2022 May 30]. Nat Chem Biol. 2022;10.1038/s41589-022-01038-y. doi:10.1038/s41589-022-01038-y (IF=16.174)
[9] Xie F, Su P, Pan T, et al. Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID-19 Therapy. Adv Mater. 2021;33(49):e2103471. doi:10.1002/adma. 202103471 (IF=30.849)
[10] Liang Y, Lu Q, Li W, et al. Reactivation of tumour suppressor in breast cancer by enhancer switching through NamiRNA network. Nucleic Acids Res. 2021;49(15):8556-8572. doi:10.1093/nar/gkab626 (IF=16.9)
[11] Fan Y, Wang J, Jin W, et al. CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer. Mol Cancer. 2021;20(1):25. Published 2021 Feb 2. doi:10.1186/s12943-021-01321-x (IF=27.403)
[12] Dai L, Dai Y, Han J, et al. Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin. Mol Cell. 2021;81(13):2765-2777.e6. doi:10.1016/j.molcel.2021.05.010 (IF=17.97)
[13] Zhang K, Wang A, Zhong K, et al. UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model. Neuron. 2021;109(12):1949-1962.e6. doi:10.1016/j.neuron.2021.04.023 (IF=17.17)
[14] Liang Y, Lu Q, Li W, et al. Reactivation of tumour suppressor in breast cancer by enhancer switching through NamiRNA network. Nucleic Acids Res. 2021;49(15):8556-8572. doi:10.1093/nar/gkab626 (IF=16.9)
[15] Li T, Chen X, Qian Y, et al. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nat Commun. 2021;12(1):615. Published 2021 Jan 27. doi:10.1038/s41467-021-20913-1 (IF=14.92)
[17] Gu C, Wang Y, Zhang L, et al. AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma. J Exp Clin Cancer Res. 2022;41(1):11. Published 2022 Jan 6. doi:10.1186/s13046-021-02220-1 (IF=11.161)
[18] Zhou Y, Li D, Luo J, et al. Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin. Cell Res. 2021;31(8):935-938. doi:10.1038/s41422-021-00510-z (IF=25.617)
[19] Luo Q, Wu X, Zhao P, et al. OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation. Adv Sci (Weinh). 2021;8(8):2002874. Published 2021 Feb 8. doi:10.1002/advs.202002874 (IF=15.84)
[20] Yan F, Huang C, Wang X, et al. Threonine ADP-Ribosylation of Ubiquitin by a Bacterial Effector Family Blocks Host Ubiquitination. Mol Cell. 2020;78(4):641-652.e9. doi:10.1016/j.molcel.2020.03.016 (IF=17.97)
[21] Sun X, Peng X, Cao Y, Zhou Y, Sun Y. ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling. Nat Commun. 2020;11(1):2984. Published 2020 Jun 12. doi:10.1038/s41467-020-16799-0 (IF=14.911)
[22] Yang X, Wang H, Xie E, et al. Rewiring ERBB3 and ERK signaling confers resistance to FGFR1 inhibition in gastrointestinal cancer harbored an ERBB3-E928G mutation. Protein Cell. 2020;11(12):915-920. doi:10.1007/s13238-020-00749-z (IF=14.872)
[23] Zou Y, Wang A, Shi M, et al. Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors. Nat Protoc. 2018;13(10):2362-2386. doi:10.1038/s41596-018-0042-5 (IF=13.490)
[24] Hao H, Hu S, Chen H, et al. Loss of Endothelial CXCR7 Impairs Vascular Homeostasis and Cardiac Remodeling After Myocardial Infarction: Implications for Cardiovascular Drug Discovery. Circulation. 2017;135(13):1253-1264. doi:10.1161/CIRCULATIONAHA.116.023027 (IF=18.881)
[1] Seki T, Yang Y, Sun X, et al. Brown-fat-mediated tumour suppression by cold-altered global metabolism. Nature. (IF 69.504)
[2] Chen P, Wang W, Liu R, et al. Olfactory sensory experience regulates gliomagenesis via neuronal IGF1. Nature. 2022. (IF 69.504)
[3] Yu Q, Liu S, Yu L, et al. RNA demethylation increases the yield and biomass of rice and potato plants in field trials. Nat Biotechnol. 2021. (IF 68.164)
[4] Dong W, Zhu Y, Chang H, et al. An SHR-SCR module specifies legume cortical cell fate to enable nodulation. Nature. 2021. (IF 69.504)
[5] Bi X, Wang K, Yang L, et al. Tracing the genetic footprints of vertebrate landing in non-teleost ray-finned fishes. Cell. 2021. (IF 66.850)
[6] Liu S, Hua Y, Wang J, et al. RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination. Cell. 2021.(IF 66.850)
[7] Lu XY, Shi XJ, Hu A, et al. Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis. Nature. 2020.(IF 69.504)
[8] Liu CX, Li X, Nan F, et al. Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity. Cell. 2019. (IF 66.850)
[9] Han X, Wang R, Zhou Y, et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell. 2018.(IF 66.850)
转染试剂产品目录
应用场景 | 名称 | 货号 | 规格 |
细胞类型:贴壁/悬浮 | 40802ES02 | 0.5 mL | |
40802ES03 | 1.0 mL | ||
40802ES08 | 5×1mL | ||
细胞类型:贴壁/悬浮 | 40803ES70 | 200 T | |
用途:病毒感染、DNA转染 | 40804ES76 | 500 μL | |
40804ES86 | 5×500 μL | ||
细胞类型:悬浮 | 40805ES02 | 0.5 mL | |
40805ES03 | 1.0 mL | ||
40805ES08 | 5×1 mL | ||
细胞类型:贴壁/悬浮 | 40806ES01 | 0.1 mL | |
40806ES02 | 0.5 mL | ||
40806ES03 | 1.0 mL | ||
细胞类型:贴壁/悬浮 | 40808ES02 | 0.5 mL | |
40808ES03 | 1 mL | ||
40808ES08 | 5×1 mL | ||
细胞类型:贴壁/悬浮 | 40809ES01 | 0.1 mL | |
40809ES03 | 1 mL | ||
细胞类型:贴壁/悬浮 | 40815ES03 | 1 g | |
40815ES08 | 5×1 g | ||
细胞类型:贴壁/悬浮 | 40816ES02 | 100 mg | |
40816ES03 | 1 g | ||
细胞类型:293 | 40820ES04 | 1.5 mL | |
40820ES10 | 10 mL | ||
40820ES60 | 100 mL |
点击产品名称查看详情
反转录定量系列产品目录
方法 | 分类 | 产品名称 | 货号 |
反转录 | 一步完成gDNA去除与反转录 | 11142ES | |
高灵敏度预混液(含gDNA去除步骤) | Hifair® III 1st Strand cDNA Synthesis SuperMix for qPCR (gDNA digester plus) | 11141ES | |
高灵敏度试剂盒 (含gDNA去除步骤) | Hifair® III 1st Strand cDNA Synthesis Kit (gDNA digester plus) | 11139ES | |
miRNA反转录试剂盒(加A法) | 11148ES | ||
快速反转录试剂盒(含gDNA去除步骤) | 11149ES | ||
qPCR染料法 | 高灵敏通用型qPCR预混液(染料法) | 11184ES | |
高灵敏型qPCR预混液(染料法) | 11198ES | ||
11199ES | |||
11200ES | |||
普通型qPCR预混液(染料法) | 11201ES | ||
11202ES | |||
11203ES | |||
miRNA qPCR加A法 | 11171ES | ||
miRNA qPCR茎环法 | 11170ES | ||
RNA一步法RT-qPCR(染料法) | 11143ES |
点击产品名称查看详情
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