Collagenase IV胶原酶IV型

[1] Wu Y, Li Y, et al. Extracellular Matrix-Trapped Bioinspired Lipoprotein Prolongs Tumor Retention to Potentiate Antitumor Immunity. Adv Mater. 2024 Apr;36(15):e2310982. doi: 10.1002/adma.202310982. Epub 2024 Jan 18. PMID: 38216153. (IF:29.4)

[2] Wang J, Zhao J, et al. Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial. Cell Metab. 2022;34(5):667-680.e6. doi:10.1016/j.cmet.2022.03.006. (IF:27.287)

[3] Yi W, Qian X, Yan D, Yan W, Hu S, Li Y, Wang D. A Dendritic Cell-Nanogel Conjugate for Tumor-Draining Lymph Node-Specific PD-L1 Blockade. Adv Mater. 2025 Oct;37(39):e2504733. doi: 10.1002/adma.202504733. Epub 2025 Jul 7. PMID: 40619999. (IF:26.8)

[4] M.-T. Niu, Q.-R.  et al. Amplifying Synergistic Effects of Cuproptosis and Bacterial Membrane Vesicles-Mediated Photothermal Therapy by Multifunctional Nano-Biohybrid for Anti-Tumor Immunotherapy. Adv. Funct. Mater. 2025, 35, 2413255. https://doi.org/10.1002/adfm.202413255. (IF:19.0)

[5] Peng T, Shao X,  et al. Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate. Sci Bull (Beijing). 2024 Dec 30;69(24):3936-3948. doi: 10.1016/j.scib.2024.08.042. Epub 2024 Nov 6. PMID: 39547906. (IF:18.8)

[6] K. Li, X. Li, et al. A Dual Enhancing Strategy of Novel Nanovaccine Based on TIM3 Silencing Nanoadjuvants and Desialylated Cancer Cell Membrane Antigens for Personalized Vaccination Immunotherapy of Cancer. Adv. Funct. Mater. 2024, 34, 2404956. https://doi.org/10.1002/adfm.202404956. (IF:18.5)

[7] Zhang C, Stewart W, Teng Y, Hu B, Xu X, Zhang XQ. mRNA-Based Vaccination Drives in Vivo Dendritic Cell Reprogramming and Selective Cytotoxic T Lymphocyte Modulation for Enhanced Antitumor Immunity. ACS Nano. 2025 Nov 11;19(44):38267-38283. doi: 10.1021/acsnano.5c09365. Epub 2025 Oct 28. PMID: 41151069.  (IF:16.0)

[8] Wang Z, Gong X, Li J, et al. Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity. ACS Nano. 2021;15(3):5405-5419. doi:10.1021/acsnano.1c00033(IF:15.881)

[9] Deng CC, Hu YF, Zhu DH, et al. Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases. Nat Commun. 2021;12(1):3709. Published 2021 Jun 17. doi:10.1038/s41467-021-24110-y(IF:14.919)

[10] Zhang QL, Hong S, Dong X, et al. Bioinspired nano-vaccine construction by antigen pre-degradation for boosting cancer personalized immunotherapy [published online ahead of print, 2022 Jun 8]. Biomaterials. 2022;287:121628. doi:10.1016/j.biomaterials.2022.121628(IF:12.479)

[11] Ma Z, Zhang W, Dong B, et al. Docetaxel remodels prostate cancer immune microenvironment and enhances checkpoint inhibitor-based immunotherapy. Theranostics. 2022;12(11):4965-4979. Published 2022 Jun 27. doi:10.7150/thno.73152(IF:11.600)

[12] Wang Y, Gong X, Li J, et al. M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors. J Nanobiotechnology. 2021;19(1):397. Published 2021 Nov 27. doi:10.1186/s12951-021-01143-5(IF:10.435)

[13] Wang H, Li J, Wang Z, et al. Tumor-permeated bioinspired theranostic nanovehicle remodels tumor immunosuppression for cancer therapy. Biomaterials. 2021;269:120609. doi:10.1016/j.biomaterials.2020.120609(IF:10.317)

[14] Chen B, Gao A, Tu B, et al. Metabolic modulation via mTOR pathway and anti-angiogenesis remodels tumor microenvironment using PD-L1-targeting codelivery. Biomaterials. 2020;255:120187. doi:10.1016/j.biomaterials.2020.120187(IF:10.317)

[15] Xu Y, Zhang J, Hu Y, et al. Single-cell transcriptome analysis reveals the dynamics of human immune cells during early fetal skin development. Cell Rep. 2021;36(6):109524. doi:10.1016/j.celrep.2021.109524(IF:9.423)

[16] Chen W, Luan J, Wei G, et al. In vivo hepatocellular expression of interleukin-22 using penetratin-based hybrid nanoparticles as potential anti-hepatitis therapeutics. Biomaterials. 2018;187:66-80. doi:10.1016/j.biomaterials.2018.09.046(IF:8.806)

[17] He R, Shi J, Xu D, et al. SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer. Cancer Lett. 2022;538:215693. doi:10.1016/j.canlet.2022.215693(IF:8.679)

[18] Chen W, Zai W, Fan J, et al. Interleukin-22 drives a metabolic adaptive reprogramming to maintain mitochondrial fitness and treat liver injury. Theranostics. 2020;10(13):5879-5894. Published 2020 Apr 27. doi:10.7150/thno.43894(IF:8.579)

[19] Zhang L, Shi J, Du D, et al. Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis. EBioMedicine. 2022;78:103959. doi:10.1016/j.ebiom.2022.103959(IF:8.143)

[20] Jain S, Hu C, Kluza J, et al. Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I. Cell Chem Biol. 2022;29(3):436-450.e15. doi:10.1016/j.chembiol.2021.11.002(IF:8.116)

[21] Yuan Q, Liang Q, Sun Z, et al. Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy. Oncoimmunology. 2021;10(1):1914954. Published 2021 Jul 21. doi:10.1080/2162402X.2021.1914954(IF:8.110)

[22] Wang Y, Chen B, He Z, et al. Nanotherapeutic macrophage-based immunotherapy for the peritoneal carcinomatosis of lung cancer. Nanoscale. 2022;14(6):2304-2315. Published 2022 Feb 10. doi:10.1039/d1nr06518a(IF:7.790)

[23] Zhang Y, Zhang J, Li X, et al. Imaging of fluorescent polymer dots in relation to channels and immune cells in the lymphatic system. Mater Today Bio. 2022;15:100317. Published 2022 Jun 12. doi:10.1016/j.mtbio.2022.100317(IF:7.348)

[24] Gao C, Zhang L, Wang J, et al. Coaxial structured drug loaded dressing combined with induced stem cell differentiation for enhanced wound healing [published online ahead of print, 2021 Nov 16]. Mater Sci Eng C Mater Biol Appl. 2021;112542. doi:10.1016/j.msec.2021.112542(IF:7.328)

[25] Jing N, Wang L, Zhuang H, Jiang G, Liu Z. Ultrafine Jujube Powder Enhances the Infiltration of Immune Cells during Anti-PD-L1 Treatment against Murine Colon Adenocarcinoma. Cancers (Basel). 2021;13(16):3987. Published 2021 Aug 7. doi:10.3390/cancers13163987(IF:6.639)

[26] Tu B , He Y , Chen B , et al. Deformable liposomal codelivery of vorinostat and simvastatin promotes antitumor responses through remodeling tumor microenvironment. Biomater Sci. 2020;8(24):7166-7176. doi:10.1039/d0bm01516d(IF:6.183)

[27] Zhao X, Hu S, Zeng L, et al. Irradiation combined with PD-L1^-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation. iScience. 2022;25(8):104690. Published 2022 Jun 30. doi:10.1016/j.isci.2022.104690(IF:6.107)

[28] Chen K, Bai L, Lu J, et al. Human Decidual Mesenchymal Stem Cells Obtained From Early Pregnancy Improve Cardiac Revascularization Postinfarction by Activating Ornithine Metabolism. Front Cardiovasc Med. 2022;9:837780. Published 2022 Feb 11. doi:10.3389/fcvm.2022.837780(IF:6.050)

[29] Luan J, Zhang X, Wang S, et al. NOD-Like Receptor Protein 3 Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis. Front Immunol. 2018;9:758. Published 2018 Apr 10. doi:10.3389/fimmu.2018.00758(IF:5.511)

[30] Liu X, Wang L, Jing N, Jiang G, Liu Z. Biostimulating Gut Microbiome with Bilberry Anthocyanin Combo to Enhance Anti-PD-L1 Efficiency against Murine Colon Cancer. Microorganisms. 2020;8(2):175. Published 2020 Jan 25. doi:10.3390/microorganisms8020175(IF:4.152)

[31] He Y, Dai J, Niu M, et al. Inhibition of nicotinamide phosphoribosyltransferase protects against acute pancreatitis via modulating macrophage polarization and its related metabolites. Pancreatology. 2021;21(5):870-883. doi:10.1016/j.pan.2021.03.011(IF:3.996)

[32] Zai W, Chen W, Luan J, et al. Dihydroquercetin ameliorated acetaminophen-induced hepatic cytotoxicity via activating JAK2/STAT3 pathway and autophagy. Appl Microbiol Biotechnol. 2018;102(3):1443-1453. doi:10.1007/s00253-017-8686-6(IF:3.420)

[33] Tong YF, Meng N, Chen MQ, et al. Maturity of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model [published correction appears in World J Gastroenterol. 2018 Oct 21;24(39):4517-4518]. World J Gastroenterol. 2018;24(10):1107-1119. doi:10.3748/wjg.v24.i10.1107(IF:3.300)

[34] Cao L, Wang J, Bo L, et al. Effects of Hypoxia on the Growth and Development of the Fetal Ovine Hepatocytes in Primary Culture. Biomed Environ Sci. 2019;32(8):592-601. doi:10.3967/bes2019.077(IF:2.656)