D-Luciferin Firefly, Free Acid D 萤火虫荧光素，游离酸

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生物发光成像（BLI）肿瘤研究药物研发

Product no.40903ES Sizes3 options SourceYeasen · Official

Cat. No. 40903ES01

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Cat.No Spec Price Status

40903ES01 100 mg ¥678.00促~~¥708.00~~ 现货 Enquire

40903ES02 500 mg ¥2,428.00促~~¥2,556.00~~ 现货 Enquire

40903ES03 1 g ¥3,408.00促~~¥3,588.00~~ 现货 Enquire

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Overview

Specifications

Brand翌圣生物 Yeasen

Cat.No40903ES

Specification中文别名（Chinese synonym）D-萤火虫荧光素游离酸；英文别名（English synonym）S)-4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic

Origin翌圣生物科技(上海)股份有限公司

技术平台 生物发光成像（BLI）

应用方法 肿瘤研究探究Hsp90-Acsl4通路的促进增加了肿瘤在体内对erastin的敏感性 药物研发评估药物的治疗功效

适用物种种属 小鼠大鼠

检测方法 生物发光检测

生物特性参数底物荧光素酶（Luciferase）的常用底物 作用机理在ATP和荧光素酶作用下被氧化发光，光量子数与荧光素酶浓度正相关

技术参数 CAS号2591-17-5 分子式C11H8N2O3S2 分子量280.33 g/mol 外观类白色至浅黄色粉末 溶解性难溶于水，可加入稀碱促进其溶解 纯度≥95% (HPLC) 储存条件-20℃干燥避光保存 运输条件冰袋运输 有效期一年

实验类型 活体成像实时监测疾病发展状态或药物的治疗功效 生物发光检测基于ATP和荧光素酶作用下的氧化发光，检测光强度变化

FAQ

Q: 怎么配置这个无菌的可注射动物体内且 ph=7.4 的稀碱？

A: 过滤。

Q: 使用的稀碱的浓度应为多少？如何调pH？

A: 使用的稀碱推荐是0.1-0.5M NaOH，使用少量稀碱溶解该试剂。待完全溶解后，根据需要配置的浓度加入PBS稀释并调整pH。

Documents & Citations

Published citations

[1] Ji C, Zhao M, Wang C, et al. Biocompatible Tantalum Nanoparticles as Radiosensitizers for Enhancing Therapy Efficacy in Primary Tumor and Metastatic Sentinel Lymph Nodes [published online ahead of print, 2022 Jun 6]. ACS Nano. 2022;10.1021/acsnano.2c02314. doi:10.1021/acsnano.2c02314(IF:15.881)

[2] Miao Z, Tian W, Ye Y, et al. Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1. Cell Death Dis. 2022;13(6):548. Published 2022 Jun 13. doi:10.1038/s41419-022-04997-1(IF:8.469)

[3] Zhang L, Sun Y, Zhang XX, et al. Comparison of CD146 +/- mesenchymal stem cells in improving premature ovarian failure. Stem Cell Res Ther. 2022;13(1):267. Published 2022 Jun 21. doi:10.1186/s13287-022-02916-x(IF:6.832)

[4] Fu RJ, He W, Wang XB, et al. DNMT1-maintained hypermethylation of Krüppel-like factor 5 involves in the progression of clear cell renal cell carcinoma. Cell Death Dis. 2017;8(7):e2952. Published 2017 Jul 27. doi:10.1038/cddis.2017.323(IF:5.965)

[5] Xu P, Wu L, Cao M, et al. Identification of MBW Complex Components Implicated in the Biosynthesis of Flavonoids in Woodland Strawberry. Front Plant Sci. 2021;12:774943. Published 2021 Nov 8. doi:10.3389/fpls.2021.774943(IF:5.754)

[6] Bai S, Tao R, Yin L, et al. Two B-box proteins, PpBBX18 and PpBBX21, antagonistically regulate anthocyanin biosynthesis via competitive association with Pyrus pyrifolia ELONGATED HYPOCOTYL 5 in the peel of pear fruit. Plant J. 2019;100(6):1208-1223. doi:10.1111/tpj.14510(IF:5.726)

[7] Yang SX, Wu TT, Ding CH, Zhou PC, Chen ZZ, Gou JY. SAHH and SAMS form a methyl donor complex with CCoAOMT7 for methylation of phenolic compounds. Biochem Biophys Res Commun. 2019;520(1):122-127. doi:10.1016/j.bbrc.2019.09.101(IF:2.705)