How to store laboratory precursor reagents in different zones in compliance with regulations?

Suggestions for daily management include keeping three accounts: inventory ledger, requisition ledger, and inspection records. Write the product name clearly in the ledger CAS、 Batch number, inventory quantity, recipient, purpose, date, counted once a month. The amount of methanol and acetone used for HPLC mobile phase is stable, and a minimum inventory can be set. If the usage is less than one week, procurement will be triggered. If the dosage of hydrochloric acid is small, it is recommended to buy small specifications and indicate the opening date to avoid long-term storage and changes in volatile concentration. Compliance costs should not only be based on the unit price of reagents, but also include monitoring, double locking, leak proof trays, labels, and manual accounting.

First, divide into three zones based on the nature of danger: methanol and acetone are classified as flammable liquids, while hydrochloric acid is classified as a corrosive acid separately; Acetone and hydrochloric acid are both involved in the production of drugs and cannot be treated as ordinary hazardous chemicals. On the safety cabinet, flammable liquids are stored in a yellow fire-resistant cabinet, corrosive acids are stored in a blue corrosion-resistant cabinet, and it is best to use specialized cabinets or safes with separate locks for easy drug production. Even if the quantity is small, don't try to save time by sharing the same cabinet; Methanol and acetone can be stored in the same cabinet, but there should be a leak proof tray. Hydrochloric acid should not be mixed with organic solvents or oxidants. Label, ventilate, and ground the cabinet, and hang the corresponding MSDS next to it.

Double double locks should not be interpreted as requiring only the first category. The third class of precursor poisons such as acetone and hydrochloric acid in the inspection are also often required to be double-locked, with access records and monitoring; methanol is generally in accordance with flammable liquid tubes, but since the inspection is reminded, it is recommended to incorporate into the precursor ledger management. Procurement filing is recommended at least 1-2 weeks in advance. The first filing will be slower at the end of the month. Compliance channels in price are usually slightly higher than ordinary reagents. The difference is mainly in qualification and transportation. It is not recommended to only look at the unit price. Fixed qualified suppliers, report the quantity on a quarterly basis to avoid temporary procurement out of stock.