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高通量测序建库Literature

Inhibition of PRMT5 triggers synthetic lethality in ARID1A-deficient endometrial cancer by promoting aberrant R-loop accumulation

Molecular Cancer · IF 42.2 · 2026 · DOI: 10.1186/s12943-026-02629-2
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Krüppel-like factor 2 programs early exhausted T cell states and restrains antiviral immunity

IMMUNITY · IF 26.3 · 2026 · DOI: 10.1016/j.immuni.2026.03.029
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Large-scale parallel characterization of RNA-guided nuclease activity and specificity

Science Bulletin · IF 20.7 · 2026 · DOI: 10.1016/j.scib.2026.03.047
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Reengineered Albumin-Paclitaxel Nanoparticles Remodeling Tumor Cell Death Pathways for Prevention of Chemotherapy-Induced Breast Cancer Metastasis

ACS Nano · IF 17.3 · 2026 · DOI: 10.1021/acsnano.6c06136
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Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi-network photoimmunotherapy of renal cell carcinoma

Smart Molecules · IF 16.8 · 2026 · DOI: 10.1002/smo2.70087
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Ginseng-derived vesicle-like nanoparticles deliver pgi-MIR6136a-p3 for sepsis therapy via ELF3/NF-κB signaling axis

JOURNAL OF NANOBIOTECHNOLOGY · IF 15 · 2026 · DOI: 10.1186/s12951-026-04540-w
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Structure-Guided Engineering of a Cas12i Nuclease Unlocks Near-PAMless Genome Editing

Advanced Science · IF 14.1 · 2026 · DOI: 10.1002/advs.202516670
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Layer-by-layer silk fibroin microparticles for codelivery for treating refractory colonic lesions

CHEMICAL ENGINEERING JOURNAL · IF 12.5 · 2026 · DOI: 10.1016/j.cej.2026.177862
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ROS-responsive nanodiscs for STING-NF-κB pathway inhibition and glycosaminoglycan layer restoration in interstitial cystitis/bladder pain syndrome therapy

JOURNAL OF CONTROLLED RELEASE · IF 11.5 · 2026 · DOI: 10.1016/j.jconrel.2026.114907
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The AGPS regulatory variant rs113671272 confers esophageal squamous cell carcinoma susceptibility through allele-specific MEIS3 binding and NF-κB activation in Chinese populations

EBioMedicine · IF 10.8 · 2026 · DOI: 10.1016/j.ebiom.2026.106249
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Hypoxic Reprogramming of ACOX1-Driven HSP90AB1 Crotonylation Stabilizes Thioredoxin to Orchestrate Redox Homeostasis in Oral Squamous Cell Carcinoma

Research · IF 10.7 · 2026 · DOI: 10.34133/research.1129
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Mitochondrial DNA released from pyroptotic synovial macrophages via DDIT3-mediated mitophagy aggravates osteoarthritis progression

Journal of Orthopaedic Translation · IF 9.8 · 2026 · DOI: 10.1016/j.jot.2025.101036
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